Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 46155-89-9, name is 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows. name: 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
1,3-Dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione 9 (2 g, 11.2 mmol) was dissolved in DMF (15 mL), K2CO3 (3.1 g, 22.4 mmol) was added and the mixture was stirred at room temperature for 10 min. After cooling at 0 C, a solution of ethyl bromoacetate (2.05 g, 12.32 mmol) in DMF (5 mL) was added dropwise and the reaction was stirred at room temperature for a further 3 h. The solvent was evaporated and the residue partitioned between EtOAc (15 mL) and water (20 mL). The aqueous phase was further extracted with EtOAc (2 × 15 mL) and the organic layers were dried over anhydrous Na2SO4. Evaporation of the solvent gave a solid residue which was filtered after suspension with a 1:1 mixture of Et2O/Petroleum ether (15 mL). White solid; 80% yield; mp 171-172 C; 1H NMR (200 MHz, CDCl3): delta (ppm) 1.29 (t, 3H, J = 7.4), 3.37 (s, 3H), 3.46 (s, 3H), 4.23 (q, 2H, J = 7), 5.10 (s, 2H), 5.99 (d, 1H, J = 3), 6.93 (d, 1H, J = 3). MS (ESI): [MH]+ = 265.3.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione.
Reference:
Article; Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1690 – 1698;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia