Related Products of 66131-68-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 66131-68-8, name is 2-Chloro-N-methylpyrimidin-4-amine. A new synthetic method of this compound is introduced below.
Potassium t-butoxide (165MG) was added to the product of example 1 step b) (0.2g) and 2-chloro-N-methyl-4-pyrimidinamine (105MG) in NMP (3ML). THE mixture was stirred at 60 C for 20h. The resulting mixture was cooled, acidified with acetic acid (LML) and purified by reverse phase HPLC (Symmetry gradient 90-50% aqueous, ammonium acetate (0.2% aq. ) in acetonitrile) to give the title compound as a solid (40mg). MS (APCI+) 383 [M+H] + H NMR 8 (DMSO 9O O 8.32 (d, lH), 7.82 (d, LH), 7.68 (dd, LH), 6.97 (s, LH), 6.81 (d, lH), 6.08 (d, LH), 5.15 (heptet, 1H), 4.05-3. 97 (m, 2H), 3.51-3. 44 (m, 4H), 3.43-3. 36 (m, 2H), 2.78 (d, 3H), 2.07-2. 00 (m, 2H), 1.87-1. 82 (m, 4H), 1.73-1. 63 (m, 2H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66131-68-8, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; WO2004/74278; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia