Reference of 150010-20-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.150010-20-1, name is 2-Bromo-5-methylpyrimidine, molecular formula is C5H5BrN2, molecular weight is 173.0106, as common compound, the synthetic route is as follows.
To a mixture of compound 7-3 (80 mg, 0.24 mmol) and 2-bromo-5- methylpyrimidine (46 mg, 0 27 mmol ) in DMT (2 mL) was added potassium carbonate (67 mg, 0.48 mmol) and 18-crown-6 (64 mg, 0.24 mmol) and the mixture was stirred at 100 C for 16 hours. The mixture was diluted with EtOAc and washed with saturated aqueous NEUCl solution and brine, dried over anhydrous NarSCX filtered and concentrated to dryness. The residue was purified by chromatography on silica gel (eluted with PE: EtOAc 2: 1) to afford compound 7-4 (47 mg, yield 45.9 %) as a yellow solid. LC/MS (ESI) m/z: 423 (M+H)?.
Statistics shows that 150010-20-1 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-5-methylpyrimidine.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; GAHHACHANDA, Venkat, Rao; EASTMAN, Kyle, J.; GODWIN, Pais; (611 pag.)WO2020/51532; (2020); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia