Synthetic Route of 6972-27-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamine (50.00 g, 0.20 mol) was added to a 500 ml clean three-neck reaction flask.And 6-chloro-1,3-dimethyluracil purified water(35.01g, 0.20mol), anhydrous sodium carbonate (63.59g, 0.60mol)And purified water (500ml), mechanically stirred, heated to 60 C for 2 hours,The temperature was lowered to room temperature, suction filtered, and the filter cake was blast dried at 50 C for 6 hours to obtain 66.23 g of urapidil.The yield was 85.2% and the purity was 97.9%.
According to the analysis of related databases, 6972-27-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hebei Yipin Pharmaceutical Co., Ltd.; Zhang Ji; Chen Wenhui; Lv Shuai; Liu Xuesong; Duan Shibao; Li Minghao; Cheng Yao; Zhao Cuiran; Zhang Yongran; (7 pag.)CN109516960; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia