New learning discoveries about 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90349-23-8, 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 90349-23-8 ,Some common heterocyclic compound, 90349-23-8, molecular formula is C9H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step (d) N-((l s,4s)-4-(5-Fluoro-2-(4 ‘-((4-(2-hydroxy ethyl)- 1 ,4-diazepan- l-yl)methyl)-2 ‘- (((SJ-S-methylmorpholinoJmethylJbiphenyl-S-yloxyJnicotinamidoJcyclohexylJ-S^- dimethylpyr azolo [ 1 ,5-a] pyrimidine-2-carboxamideTo a suspension of N-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(4′-((4-(2-hydroxyethyl)-l,4- diazepan- 1 -yl)methyl)-2’-(((S)-3 -methylmorpholino)methyl)biphenyl-3 -yloxy Nicotinamide hydrochloride (200 mg, 0.24 mmol) in acetonitrile (2.74 ml) was added 5,7- dimethylpyrazolo[l,5-a]pyrimidine-2-carboxylic acid (48.9 mg, 0.26 mmol) and triethylamine (0.340 ml, 2.44 mmol). 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (0.171 ml, 0.27 mmol) was then added and the mixture stirred at RT for 2 hours. The mixture was evaporated to dryness and the residue dissolved in DCM (150 ml) and washed with saturated NaHCC^aq), brine, dried (MgSC^) and evaporated to give a foam. The crude product was purified by preparative HPLC using a 95-5% gradient of aqueous 0.2% ammonia in methanol as eluent to give the title compound as a white solid. Yield: 33 mg 1H NMR (W MHz, CDCl3) delta 8.11 – 8.03 (m, 2H), 7.48 – 7.37 (m, 2H), 7.22 – 7.14 (m, 3H), 7.12 – 7.07 (m, 2H), 6.88 (d, J= 6.9 Hz, 2H), 4.20 – 4.09 (m, IH), 4.06 – 3.96 (m, IH), 3.89 (d, J= 13.1 Hz, IH), 3.63 – 3.54 (m, 4H), 3.52 – 3.31 (m, 9H), 3.31 – 3.26 (m, 2H) 3.09 – 2.96 (m, 2H), 2.81 – 2.70 (m, 4H) 2.69 – 2.59 (m, 4H), 2.53 (s, 3H), 2.44 – 2.36 (m, IH), 2.23 – 2.11 (m, IH), 1.96 – 1.68 (m, 10H), 0.75 (d, J= 6.2 Hz, 3H). MS: [M+H]+=848 (calc=848) (MultiMode+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90349-23-8, 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia