Reference of 4316-93-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4316-93-2 as follows.
General procedure: To a solution of the nitrochloropyrimidine derivative in tetrahydrofuran (4 mL/mmol) were added the amine (1 equivalent) and NaHC03 (1.1 equivalents). The solution was stirred at room temperature overnight. After concentration under reduced pressure, the crude product was purified by chromatography on silica gel to afford the pure product. This compound was synthetised through general synthesis protocol XVI from 4,6-dichloro-5-nitropyrimidine (1 equivalent) and 4-aminoacetanilide (1 equivalent). It was stuffed at room temperature under argon for 7 h. The suspension was then filtered and the precipitate was washed with ethyl acetate. The filtrate was concentrated until precipitation. The precipitate was filtrated to afford pure compound120 (25%). ?H NMR (400 MHz, d6-DMSO) oe 10.02 (bs, 1H, NH), 9.99 (bs, 1H, NH),8.47 (s, 1H, CH), 7.57 (d, J = 8.9 Hz, 2H, 2 CH), 7.39 (d, J = 8.9 Hz, 2H, 2 CH),2.04 (s, 3H, CH3); HRMS (ESI) calc. for C,2H,,C1N503: [M + H] 308.05449, found308.0543.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4316-93-2, its application will become more common.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE PIERRE ET MARIE CURIE – PARIS 6 (UPMC); CALLEBAUT, Isabelle; MORNON, Jean-Paul; DECOUT, Jean-Luc; BECQ, Frederic; LEHN, Pierre; HOFFMANN, Brice; BOUCHERLE, Benjamin; HAUDECOEUR, Romain; FORTUNE, Antoine; BOINOT, Clement; ALLIOT, Julien; (147 pag.)WO2016/87665; (2016); A2;,
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