A new synthetic route of 2-Chloro-5-ethylpyrimidine

Statistics shows that 111196-81-7 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-ethylpyrimidine.

Synthetic Route of 111196-81-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111196-81-7, name is 2-Chloro-5-ethylpyrimidine, molecular formula is C6H7ClN2, molecular weight is 142.59, as common compound, the synthetic route is as follows.

General procedure: To a vial with septa containing tert-butyl 2-[(R)-5-bromo-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate 3 (2.42 mmol) were added bis(pinacolato)diboron (2.61 mmol), potassium acetate (12.12 mmol), and Pd(dppf)Cl2 (0.039 mmol). The vial was purged with a stream of nitrogen, and anhydrous 1,4-dioxane (12 mL) was added. The resulting mixture was purged with nitrogen for three times, and the mixture was heated at 95 C for 1 h. The aryl halide 5 (2.61 mmol), Pd(dppf)Cl2 (0.062 mmol), and 9 ml of 2 M aqueous potassium carbonate solution (de-oxygenated by bubbling through N2 for 15 min) were added. The mixture was purged with N2 three times and heated at 95 C for 17 h. The mixture was cooled to room temperature and the organic layer was separated from the aqueous layer. The organic layer was filtered through a thin plug of silica gel, and rinsed with 5 mL of isopropyl alcohol followed by 5 mL of MeOH. The filtrate and the washings were concentrated under reduced pressure to give the crude product that was purified by silica gel chromatography eluting with a gradient of 010% MeOH in CH2Cl2 to give the desired product.

Statistics shows that 111196-81-7 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-ethylpyrimidine.

Reference:
Article; Fernando, Dilinie P.; Jiao, Wenhua; Polivkova, Jana; Xiao, Jun; Coffey, Steven B.; Rose, Colin; Londregan, Allyn; Saenz, James; Beveridge, Ramsay; Zhang, Yingxin; Storer, Gregory E.; Vrieze, Derek; Erasga, Noe; Jones, Ryan; Khot, Vishal; Cameron, Kimberly O.; McClure, Kim F.; Bhattacharya, Samit K.; Orr, Suvi T. M.; Tetrahedron Letters; vol. 53; 47; (2012); p. 6351 – 6354,4;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia