Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. A new synthetic method of this compound is introduced below., Quality Control of (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate
A solution of the above (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl] -3-methoxypropenoate in toluene Poured into 500mL three-necked reaction flask, 15.0 g (95%, 0 · 12 mol) of salicylonitrile was added, 10.7 g of sodium carbonate (99% (L) was stirred, heated to 90-95 C for 5 h, and the HPLC analysis showed that (Epsilon) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl] -3 The reaction mixture was cooled to room temperature, filtered and the solid was washed twice with 50 mL of toluene. The filtrate and the washing solution were combined. The toluene was recovered by distillation under reduced pressure, 70 mL of methanol was added, stirred and cooled to 5-KTC , Crystallization, filtration, filter cake with 20mL methanol washing twice, drying, weight 36.7g, content 98.2%, yield 89.4%.
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Reference:
Patent; Chongqing Ziguang International Chemical Co., Ltd.; Ding Yongliang; Liu Jia; Zhang Fei; You Huan; Wu Chuanlong; Jin Haiqin; Zheng Daomin; Yao Rujie; (15 pag.)CN104230822; (2017); B;,
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