Application of 95928-49-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 95928-49-7, name is Ethyl 2-hydroxypyrimidine-5-carboxylate, molecular formula is C7H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 4:Ethyl 2-chloropyrimidine-5-carboxylateEthyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate (100 g, 0.59 mol) was slurried in POCl3 (600 mL) and cooled in an ice/water bath.The reaction mixture was heated to reflux temperature (oil-bath, T=117° C.) for 2 h.The light-brown colored homogeneous reaction mixture was cooled and the excess of POCl3 was removed by vacuum distillation.The semisolid brown residue was cooled (ice-water bath), toluene (400 mL) and a mixture of water (400 mL) and ice (200 g) were added.The mixture was stirred for 2 h and filtered.The organic phase was separated, dried and concentrated to dryness on a rotary evaporator.The dark yellow residue was purified by flash chromatography (SiO2, heptane/ethyl acetate 9/1) to afford the title compound.1H NMR (500 MHz, DMSO-d6): delta 9.18 (s, 2H); 4.38 (q, 2H); 1.34 (t, 3H).
According to the analysis of related databases, 95928-49-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.; US2011/152295; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia