Reference of 26830-94-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 mm. After stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (5i02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes andfiltered to give Compound 3 as an orange crystalline solid (9.74 g). Yield 41%1H NMR (400 MHz, DMSO-d6): oe 8.40 (br s, 1H), 8.16 (br s, 1H), 8.10 (s, 1H); LC/MS: nz/z= 192.2 [M+Hf (Calc: 191.4).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.
Reference:
Patent; PURDUE PHARMA L.P.; TAFESSE, Laykea; PARK, Jae, Hyun; WO2015/123398; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia