With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.171887-03-9, name is N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide, molecular formula is C5H4Cl2N4O, molecular weight is 207.02, as common compound, the synthetic route is as follows.Computed Properties of C5H4Cl2N4O
2-Amino-4,6-dichloro-5-formamidopyrimidine (0.8g; 3.8mmol) and DIPEA (1.7mL; 10.0mmol) were added to a solution of 4-amino-3-hydroxy-1-trityloxymethylphospholane 1-oxide 15 (1.0g; 2.5mmol) in n-butanol (25mL). The reaction mixture was stirred for 16h at 130C and evaporated. The residue was treated 16h at 60C with concentrated hydrochloric acid/ methanol 1/ 10 (25mL), diluted with water (100mL) and treated with Dowex H+ (10g). The resin was filtered off and washed with methanol (100mL) and water (100mL). The product was washed off of the resin with 5% aqueous ammonia (100mL), evaporated, purified by preparative HPLC (isocratically water) and freeze-dried from water to yield 0.34g (45%) of white lyofilisate. HRMS (FAB) calcdfor C10H15N5O4P (M+H)+ 300.0862, found 300.0865. IRnumax (KBr) 3403, 3322, 3200, 3161, 3113, 1736, 1689, 1633, 1610, 1572, 1539, 1484, 1408, 1390, 1324, 1218, 1152, 1073, 1054, 784, 777, 729, 639. NMR data-see Tables 2-4
At the same time, in my other blogs, there are other synthetic methods of this type of compound,171887-03-9, N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide, and friends who are interested can also refer to it.
Reference:
Article; Pav, Ond?ej; Zbornikova, Eva; Bud??insky, Milo?; Rosenberg, Ivan; Tetrahedron; vol. 69; 43; (2013); p. 9120 – 9129;,
Pyrimidine | C4H4N2 – PubChem,
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