Electric Literature of 13162-43-1 ,Some common heterocyclic compound, 13162-43-1, molecular formula is C5H3Cl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 4,6-dichloro-2-methyl-5-nitropyrimidine (3; J. Chem. Soc. 1954, 3836) (2.23 g, 11 mmol) in EtOH (30 mL) at -30 C. was treated with 1-ethylpropylamine (870 mg, 10 mmol) in EtOH (8 mL) and the reaction mixture was stirred at -30 C. for 1 hour and then warmed to ambient temperature. Volatiles were evaporated and the residue was partitioned between water and EtOAc. The organic layer was dried (sodium sulfate), evaporated, purified by flash chromatography (silica) to give compound (4).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13162-43-1, its application will become more common.
Reference:
Patent; Neurocrine Biosciences, Inc.; US6348466; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia