Reference of 90905-33-2 ,Some common heterocyclic compound, 90905-33-2, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4-chloro-N2-methylpyridine-2, 3-diamine (840 mg, 5.33 mmol) and iron (III) chloride hexahydrate (360 mg, 1.33 mmol) were dissolved in DMF (26 ml). 2-Methylpyrimidine-5-carbaldehyde (716 mg, 5.86 mmol) was then added and the reaction was allowed to stir vigorously at 80 open to air for 18 h The reaction mixture was then diluted with 3:. 1 chloroform: IPA and washed with water The combined organic layers. were washed with brine, dried over MgSO 4, and concentrated in vacuo while loading onto silica gel Purification by column chromatography. (silica gel, eluting with a gradient of 0 -60percent 3: 1 EtOAc: EtOH in hexanes) gave 7-chloro -3-ethyl-2- (2- methylpyrimidin-5-yl) -3H-imidazo [4, 5-b] pyridine (Intermediate IV). MS ESI calc’d. for C 13 H 13 ClN 5 [M + 1]+ 274; found 274.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90905-33-2, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth Ann; ZHOU, Hua; KATZ, Jason D.; YANG, Lihu; METHOT, Joey; LIPFORD, Kathryn Ann; XU, Shimin; FU, Ning; XU, Guoquan; BIAN, Deqian; FU, Jianmin; LI, Yabin; FONG, Kin Chiu; (124 pag.)WO2017/125; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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