Reference of 705263-10-1, Adding some certain compound to certain chemical reactions, such as: 705263-10-1, name is 6-Bromopyrazolo[1,5-a]pyrimidine,molecular formula is C6H4BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 705263-10-1.
The intermediate of formula VI (30 mmOl, 5.9 g)And the substance of formula VII (30 mmol, 4.6 g)Was placed in a 250 ml round bottom flask equipped with a reflux condenser, potassium carbonate (90 mmol, 12.4 g) and Pd (PPh3) 4 (3 mmol, 3.3 g) were added, dioxane (90 ml) and water (30 ml ), Stirred under nitrogen for three times, heated under nitrogen to 110 C, stirred for 4 h,After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed under reduced pressure. The mixture was extracted with 100 ml of water and 100 ml of dichloromethane. The organic phase was separated and the aqueous phase was extracted with dichloromethane 50 ml chi 3 for 3 times. Dried over sodium sulfate, the solvent was removed by suction filtration, and the residue was purified by column chromatography with ethyl acetate / petroleum ether to give 5.5 g of a pale yellow product.The pale yellow product is an intermediate of formula III-1,The yield of the intermediate of formula III-1 was calculated to be 82%.
According to the analysis of related databases, 705263-10-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chengdu Zhipulai Bio-pharmaceutical Technology Co., Ltd.; Chen Wei; Zhao Gang; Pu Lin; Liu Jifeng; (13 pag.)CN105130991; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia