As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Amino-4,6-dimethoxypyrimidine
In a 3000 liter glass-lined reactor, 2000 kg of metered methylene chloride, 580 kg of [3-(N,N-dimethylaminocarbonyl-2-pyridyl)sulfonylamino]carboxylic acid phenyl ester and 215 kg of pyrimidinamine were added, heated to 40 C (heating rate of 5 C / h), and stirred for 5 hours. Pyrimidineamine was detected by thin layer chromatography, the end point was an unreacted pyrimidine amine with a mass concentration of less than 2%. The developing solvent for thin layer chromatography was a mixed solvent of chloroform and methanol (volume ratio of 2:1). Until the end of the reaction, a solution of 150 kg of sodium carbonate and 400 kg of water were added, stirred, layers were separated, and the aqueous layer were neutralized with hydrochloric acid (30%) to precipitate nicosulfuron crystallization hydrate. The filtrate was cooled to 15 C, filtered (reduced rate was 10 C / h), and the filter cake was dried at 50 C for 4 hours and then sampled and measured. When the material was measured to constant weight and dried, and 543 kg of the finished nicosulfuron crystallization hydrate was obtained, the yield was 95.47%, and the content of the external standard method was 98.11%.
With the rapid development of chemical substances, we look forward to future research findings about 36315-01-2.
Reference:
Patent; Zibo Xin Nongji Crop Science Co., Ltd.; Zheng Youkui; Cui Yuanxing; Shao Changlu; Huang Hua; (11 pag.)CN110330480; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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