According to the analysis of related databases, 13544-44-0, the application of this compound in the production field has become more and more popular.
Related Products of 13544-44-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2) (R)-2-(2-chloro-5-iodopyrimidine-4-ylamino)propan-1-ol:; In the reaction of 2,4-dichloro-5-iodopyrimidine (3.0 g, 10.9 mmol) with (R)-2- amino-1-propanol (884 mg, 11.8 mmol) according to procedure 2, the desired product is obtained in 88 % yield (1.6 g) after chromatographic purification (silica gel, dichloromethane/methanol (0% to 20% methanol)).1H-NMR (300 MHz1 DMSO-D6): 5 1.10 (d, 3H), 3.35-3.45 (m, 2H), 4.05-4.15 (m, 1 H), 4.86 (t, 1 H), 6.56 (d, 1 H), 8.30 (s, 1 H).; Procedure 2 – Introduction of amine in the 4 position of the pyrimidine:; 5-bromo-2,4-dichloro-pyrimidine or 2,4-dichloro-5-iodo-pyrimidine (1.0 equiv.) is dissolved in acetonitrile (62.0 equiv.) and treated with triethylamine (1.2 equiv.) and the amine component (1.1 equiv.). After 24 hours at room temperature, the mixture is diluted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, 10 % aqueous citric acid solution and saturated sodium hydrogen carbonate solution. After drying over sodium sulphate and removal of the solvent, the purification is effected by chromatography.The reaction of 5-bromo-2,4-dichloro-pyrimidine or 2,4-dichloro-5-iodo- pyrimidine with amines, alcohols or thiols is also described in: a) U. Lucking, M. Krger, R. Jautelat, G. Siemeister, WO 2005037800; b) U. Lucking, M. Krueger, R. Jautelat, O. Prien, G. Siemeister, A. Ernst, WO 2003076437; c) T. Brumby, R. Jautelat, O. Prien, M. Schafer, G. Siemeister, U. Lucking, C. Huwe, WO 2002096888).
According to the analysis of related databases, 13544-44-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING AKTIENGESELLSCHAFT; WO2007/71455; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia