With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, molecular weight is 174.585, as common compound, the synthetic route is as follows.Recommanded Product: 6320-15-6
[00166] lambdaf-[2-({(3JR)-l-[l-(2,6-dimethoxypyrimidin-4-yl)azepan-4-yl]pyrrolidin-3-yl}amino)-2- oxoethyl]-3-(trifluoromethyl)benzamide (20); [00167] To a solution of N-(2-{[(3R)-l-azepan-4-ylpyrrolidin-3-yl]amino}-2-oxoethyl) (trifluoromethyl)benzamide (75 mg, 0.18 mmol) in DMF (1 mL), was added 4-chloro-2,6- dimethoxypyrimidine (32 mg, 0.18 mmol) and diisopropylethylamine (35 muL, 0.20 mmol). The reaction was stirred overnight at 900C, then was cooled to room temperature. To the mixture was added NaHCO3 (sat. aq., 10 mL) and dichloromethane (10 mL). The organic layer was separated and the aqueous layer was washed with an addition portion of dichloromethane (10 mL). The organic layers were combined, dried over Na2SO4, filtered and concentrated. The resulting crude product was subjected to flash chromatography (15% MeOH, 1% NH4OH in EtOAc) to afford, as an approximately 1:1 mixture of diastereomers, benzyl 4-{ (3R)-3-[({ [3-(trifluoromethyl)benzoyl]amino }acetyl)arnino]pyrrolidin-l-
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2007/53495; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia