Synthetic Route of 13223-25-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13223-25-1 as follows.
A mixture of (2R*, 4S*) -4-amino-2-ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-l-carboxylic acid ethyl ester (300 mg), 2-chloro-4,6- dimethoxypyrimidin (468 mg), N, N-diisopropylethylamine (0.467 ml) and 1,4-dioxane (5 ml) is heated under reflux for 2 days. The reaction solution is concentrated under reduced pressure, and the resulting residue is purified by column chromatography (silica gel; hexane: ethyl acetate = 80 : 20-60 : 40) to give (2R*, 4S*)-4- (4, 6-dimethoxypyrimidin-2-yl) amino-2- ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-1-carboxylic acid ethyl ester (280 g). MS (m/z) : 418 [M+H] +
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13223-25-1, its application will become more common.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2005/95395; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia