Reference of 1197953-49-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. A new synthetic method of this compound is introduced below.
Compound a6 (150 mg, 0.5 mmol) was dissolved in acetone/water (3:1 by volume,A total of 8 mL), adding compound b3-1 (200 mg, 0.6 mmol), 3 drops of concentrated hydrochloric acid, sealed, heated to 100 C, stirred overnight.Cool to room temperature and adjust to pH 12 with 10% aqueous sodium hydroxide.Extract three times with dichloromethane, dry the organic phase, filter and concentrate.Column chromatography was carried out with ethyl acetate, dichloromethane/methanol (10:1 by volume) as mobile phase.Yield 110 mg of a pale yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1197953-49-3, its application will become more common.
Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
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