Reference of 1627-28-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1627-28-7, name is 6-Chloro-5-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.
A stirred solution of 6-chloro-5-methylpyrimidine-2,4(1 H,3H)-dione a5 (4.80 g, 0.30 mmol) and Nal (23.4 g, 150 mmol) in HI (60 mL) was stirred in sealed tube at room temperature for 66 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was filtered and washed with cold water (50 mL) and dried under vacuum to afford 2.1 g of 6-iodo-5-methylpyrimidine-2,4(1 H,3H)-dione a6 was isolated as a brown solid, which was used in next step without any further purification. LCMS (ES+): 253 (M+H)+. 1H NMR (400 MHz, DMSO -cfe) 5 1 1.21 (s, 1 H), 1 .90 (s, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1627-28-7, 6-Chloro-5-methylpyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; UCB BIOPHARMA SPRL; MERCIER, Joel; VALADE, Anne; VERMEIREN, Celine; WOOD, Martyn; MAGUIRE, Ralph; (52 pag.)WO2019/105913; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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