In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39889-94-6, name is 5-Amino-2-methylpyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Amino-2-methylpyrimidine
Intermediate 103A (170 mg) in DCM (2 mL) was added to 2-methylpyrimidin-5-amine (46.2 mg, 0.423 mmol) in DCM (1 mL), followed by addition of pyridine (0.14 mL, 1.76 mmol). The reaction mixture was stirred at room temperature for lh, at which time LCMS indicated a completion of reaction. The reactionmixture was diluted with EtOAc, washed with 0.5 N HC1. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The crude was dissolved in DMSO and purified via preparative LC/MS (method A, 50-100% B over 10 minutes, then a 2-minute hold at 100% B). Fractions containing the desired product were combined and dried via centrifugal evaporation to yield Example 103 (80 mg, 43% yield) as a solid. ?HNMR (400MHz, chloroform-d) 8.78 (s, 2H), 8.63 (d, J1.5 Hz, 1H), 8.56 (s, 1H), 7.77(d, J0.9 Hz, 1H), 7.69 (d, J8.6 Hz, 1H), 7.13 (d, J=8.8 Hz, 1H), 4.64-4.49 (m, 4H), 4.32(dd, J=11.4, 6.6 Hz, 1H), 4.14 (s, 3H), 2.73 (s, 3H), 2.66 (s, 3H). LC-MS: method C, RT= 2.37 mm, MS (ESI) mlz: 531.1 (M+H) Analytical HPLC purity: 95%.
The synthetic route of 39889-94-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; JIANG, Wen; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (545 pag.)WO2018/13776; (2018); A1;,
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