Analyzing the synthesis route of 7400-06-8

The synthetic route of 7400-06-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 7400-06-8 , The common heterocyclic compound, 7400-06-8, name is 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol, molecular formula is C10H17N3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step2 7H-Pyrrolo[2,3-d]pyrimidine-4-ol12.8M Hydrochloric acid (1.2 ml) was added to a suspension of 6-Amino-5-(2,2-diethoxy- ethyl)-pyrimidin-4-ol (2.23g 9.8 mmol) in water (60 ml) was stirred at ambient temperature for 2.5 hrs. The mixture was then cooled with an ice water bath and then filtered. The filtered solids were dried in vacuo to afford title compound as a yellow solid 1.2g (90percent).LC/MS: RT = 0.572 min; m/z = 158 [M+Na]+. Total run time 3.75 mins. 1H NMR (dbeta DMSO): delta 6.40 (dd, 1H); 7.03 (dd, 1 H); 7.82 (s, 1H); 11.74 (brs, 1H); 11.83 (brs, 1H).

The synthetic route of 7400-06-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VERNALIS (R & D) LTD.; WO2007/104944; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia