Adding a certain compound to certain chemical reactions, such as: 611-08-5, 5-Nitrouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 5-Nitrouracil, blongs to pyrimidines compound. name: 5-Nitrouracil
25 gm of 5-nitro uracil is suspended in 490 ml of phosphorous oxychloride for 10 minutes and diisopropyl ethylamine is slowly added to the suspension at room temp. The reaction suspension is refluxed at 130 oC for 3h. The solution is concentrated under reduced pressure to be a volume of 100 ml. Then the solution is added dropwise to 500 ml of ice water and stirred for 1h, and extracted with diethyl ether. The organic layer is washed with 500 ml of saturated ammonium chloride and dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Column chromatography on silica gel (ethyl acetate: Hexane=1:5) affords 16.8 gm of the title compound. White solid; mp:30-32 oC; IR (KBr): 1670, 1620, 1350, 785 cm-1; 1H NMR (400 MHz, CDCl3): delta 9.25 (s, 1H, H6) ppm; m/z=195(M+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,611-08-5, 5-Nitrouracil, and friends who are interested can also refer to it.
Reference:
Article; Sadanandam; Jyothi; Adharvana Chari; Das, Parthasarathi; Mukkanti; Tetrahedron Letters; vol. 52; 42; (2011); p. 5521 – 5524;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia