Adding a certain compound to certain chemical reactions, such as: 160199-05-3, 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 160199-05-3, blongs to pyrimidines compound. Computed Properties of C10H4Cl2N2S
General procedure: 2,4-dibromopyrimidine (CAS Registry Number: 3921-01-5) (24.46 g, 102.82 mmol) was added to a round bottom flask and dissolved in THF (360 ml)4,4,5,5-tetramethyl-2- (naphthalen-1-yl-ethyl) -1,3,2-dioxaborolane(CAS Registry Number: 1280709-91-2) (29.54 g, 113.11 mmol),Pd (PPh3) 4 (4.75 g, 4.11 mmol),K2CO3 (42.63 g, 308.47 mmol) and water (180 ml) were addedAnd stirred at 90 C.After the reaction was completed, the reaction mixture was extracted with CH 2 Cl 2 and water. The organic layer was dried over MgSO 4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 18.03 g (yield: 60%) of the product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,160199-05-3, its application will become more common.
Reference:
Patent; Duksan Neolux Co.,Ltd.; Song Hyeon-ju; Park Mu-jin; Jeong Ho-yeong; Lee Mun-jae; Lee Seon-hui; Kwon Jae-taek; (49 pag.)KR2018/97955; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia