Electric Literature of 4316-93-2 , The common heterocyclic compound, 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a stirred solution of chloro nitro pyridine / pyrimidine (1.0 equiv) in EtOH (0.5 mL per 0.52 mmol) was added DIPEA (3.0 equiv) followed by amine (1.05 equiv) at 0oC. The reaction mixture was stirred at 60-80oC for 3-6 h (the reaction was monitored by TLC). After completion of the reaction EtOH was distilled-off under a reduced pressure. The residue was dissolved in EtOAc (50 mL per 1g of crude). The organic layer was washed with water (20 mL), and brine (20 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resultant crude compound was purified by silica gel column chromatography (100-200 mesh) using 10-20 % ethyl acetate – hexane to afford the desired compound (yield: 85-95 %).
The synthetic route of 4316-93-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Marepu, Nagaraju; Yeturu, Sunandamma; Pal, Manojit; Bioorganic and Medicinal Chemistry Letters; vol. 28; 20; (2018); p. 3302 – 3306;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia