Electric Literature of 135481-57-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.135481-57-1, name is 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione, molecular formula is C14H15N3O2, molecular weight is 257.29, as common compound, the synthetic route is as follows.
To 6-benzyl-5, 6, 7, 8-tetrahydropyrido [4, 3-d] pyrimidine-2, 4(1 H, 3H)-dione (7.2 g, 27.9 mmol), POCI3 (45mL, 6V) was added slowly at 0C and refluxed for 4h. The reactionmixture was evaporated under vacuum. EtOAc (200 mL) was added and the solution was poured over cold 3M NaOH solution. The resulting organic layer was separated and washed with brine (30 mL), dried over anhydrous Na2SO4 and evaporated, affording the title compound. Yield: 79% (6.5 g, brown solid). 1H NMR (400 MHz, DMSO-d6): 6 7.33- 7.32 (m, 5H), 3.77 (s, 2H), 3.56 (s, 2H), 2.94 (t, J = 7.2 Hz, 2H), 2.80 (t, J = 6.8 Hz, 2H).LCMS: (Method A) 296.3 (M +2), Rt. 2.50mm, 97.94% (Max).
The chemical industry reduces the impact on the environment during synthesis 135481-57-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
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