Adding a certain compound to certain chemical reactions, such as: 4316-94-3, 6-Chloro-5-nitropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Chloro-5-nitropyrimidin-4-amine, blongs to pyrimidines compound. name: 6-Chloro-5-nitropyrimidin-4-amine
Compound 1 (1.91 g, 11 mmol) and diisopropylethylamine (1.55 g, 12 mmol) were added to a solution of the compound compound mono-tert-butoxycarbonyl protected piperazine (1.86 g, 10 mmol) in dimethylformamide (10 mL) ), The reaction was carried out at room temperature for 8 hours. The solvent was removed under reduced pressure and the residue was subjected to flash column chromatography (dichloromethane: methanol = 50: 1) to give the title compound as a white solid. B: 4- (6-Amino-5-nitropyrimidine- 4-yl) piperazine-1-carbonate (2.82 g, yield 87%).
The synthetic route of 4316-94-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Huilun Life Technology Co., Ltd.; Fan Xing; Qin Jihong; (31 pag.)CN106146504; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia