In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10070-92-5, Pyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Related Products of 10070-92-5 ,Some common heterocyclic compound, 10070-92-5, molecular formula is C5H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Intermediate 109: (+/-)-1 ,1-Dimethylethyl 4-rcvano(5-pyrimidinyl)methyll-1- piperazinecarboxylate; To a solution of 1 g of 5-pyrimidinecarbaldehyde (9.2 mmole, Aldrich) in 10 mL of dichloroethane in a dry flask under nitrogen were added 1.7 g of 1 ,1-dimethylethyl 1- piperazinecarboxylate (9.2 mmole, Fluka) followed by 3.8 mL of Ti(iOPr)4 (12.8 mmole, Aldrich). The solution was then stirred at RT overnight. 11 mL of a solution of Et2AICN 1 M in toluene (11 mmole, Aldrich) were added dropwise at RT and the mixture was stirred at RT for 4 h. Then 3×10 mL of a saturated solution of NaHCO3 in water was added dropwise and the mixture was stirred at RT overnight. The resulting precipitate was filtered on celite and the cake was washed with AcOEt. The organic phase was washed with a saturated solution of NaHCO3 in water and the layers were separated on a phase separator cartridge. Solvents were removed under reduced pressure and the resulting crude compound was purified by flash chromatography on a 25 g silica gel cartridge with AcOEt/CH 1 :1 as an eluent to give the title compound as a sand color solid (1.72 g). 1H- NMR (400 MHz, CDCI3): delta 1.46 (9H, s), 2.56 (4H, m), 3.41 (4H, m), 5.11 (1 H, s), 8.81 (2H, s), 8.94 (1 H, s); UPLC-MS [Acquity UPLC BEH C18, 50×21 mm, 1.7 mum, gradient: A: H2O +0.1 % HCOOH/B: MeCN+0.075% HCOOH: 1 % to 6%B in 0.2 min., 6% to 60%B in 1.05 min, 60% to 100%B in 0.5 min., 100%B for 0.2 min, flow rate: 1 mL/min]: R1 = 0.64 min. m/z (ES): 326 [M+Na]+, 248 [M-CN]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10070-92-5, Pyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/148853; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia