Synthetic Route of 89793-12-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In step 4 manufactured benzyl 4-amino-4-phenylpiperidine-1-carboxylate hydrochloride (3.000 g, 8.649 mmol), ethyl 2-chloropyrimidine-5-carboxylate (1.614 g, 8.649 mmol) and N,N-diisopropylethylamine (3.465 mL, 19.893 mmol) was dissolved in 1,4-dioxane (30 mL) at room temperature and stirred at 110 °C for 17 hours, and then the reaction was terminated by lowering the temperature to room temperature. The solvent was removed from the reaction mixture under reduced pressure and the concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 5percent to 40percent) and concentrated to give the title compound (1.900 g, 51.5percent was obtained in the form of a yellow solid.
According to the analysis of related databases, 89793-12-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia