Introduction of a new synthetic route about 2-(Chloromethyl)pyrimidine hydrochloride

With the rapid development of chemical substances, we look forward to future research findings about 936643-80-0.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 936643-80-0

To a stirred solution of 38-D (75 mg, 0.232 mmol) in DMF (6 mL) was added K2CO3 (128 mg, 0.928 mmol), followed by 38-E (57 mg, 0.348 mmol). The resulting mixture was stirred at 70 C. overnight. Diluted the reaction mixture with EtOAc and washed with H2O. The organic layer was dried over Na2SO4 and evaporated in vacuo. The residue was then purified by column chromatography (EtOAc:hexanes=2:3) to afford Compound II-56.

With the rapid development of chemical substances, we look forward to future research findings about 936643-80-0.

Reference:
Patent; Gilead Sciences, Inc.; US2012/289493; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia