Reference of 89466-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89466-55-7, name is 4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine, molecular formula is C6H7ClN2O3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 2 Preparation of 2-anilino-4-chloro-6-methoxypyrimidine (Compound 1) 1.8 g of formanilide was dissolved in 50 ml of tetrahydrofuran, and 0.4 g of sodium hydride from which the oily matter had been removed beforehand with n-hexane was slowly added to the resulting solution at 10 to 20C while cooling with ice water. To the suspension thus obtained was added 3.3 g of 4-chloro-2-methanesulfonyl-6-methoxypyrimidine, and the mixture was stirred for 1 hour at room temperature. Then, 15 ml of 4N hydrochloric acid was added, and reaction was effected for 1 hour under reflux. The reaction liquid was poured in water, extracted with ether, and the ether layer was washed with water, dried over magnesium sulfate, and then the ether was stripped by concentration. The residual crystals were recrystallized from n-hexane, and 4.0 g of 2-anilino-4chloro-6-methoxypyrimidine was obtained (yield 87%). Melting point: 101-103C.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89466-55-7, 4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine.
Reference:
Patent; KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY Co., Ltd.; EP224339; (1991); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia