Reference of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.
A microwave vial was charged with 5-amino-4,6-dichloro-2-methyl-pyrimidine (4) (700 mg, 3.91 mmol), 4-methoxybenzylamine (510 ml, 3.91 mmol), and K2CO3 (810 mg,5.86 mmol) in anhydrous DMF (10 mL). The vessel was sealed and irradiated at 150 C for 1 h. After cooling, dichloromethane was added (20 mL) and the crude reaction mixture was washed with saturated aqueous NH4Cl (15 mL). The organic layer was dried over Na2SO4, filtered and evaporated to dryness. The residue was purified by flash chromatography (dichloromethane:methanol 20:1) to yield 696 mg (64%) of 11 as a yellow solid. Mp 155-157 C. MS (ES, positive mode):m/z 279 (M+H)+ with a Cl isotopic pattern. 1H NMR (DMSO-d6, 300 MHz) delta: 2.52 (s, 3H, CH3-2), 2.68 (s, 3H, CH3-8), 3.71(s, 3H, OCH3), 5.39 (s, 2H, CH2), 6.89 (d, 2H, J=8.6 Hz, Ar), 7.17 (d,2H, J=8.5 Hz, Ar).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Canela, Mara-Dolores; Liekens, Sandra; Camarasa, Mara-Jos; Priego, Eva Mara; Prez-Prez, Mara-Jess; European Journal of Medicinal Chemistry; vol. 87; (2014); p. 421 – 428;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia