Simple exploration of 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

According to the analysis of related databases, 1211443-61-6, the application of this compound in the production field has become more and more popular.

Application of 1211443-61-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. This compound has unique chemical properties. The synthetic route is as follows.

Preparation of 3-[6-(7-Cyclopentyl-6-dimethylcarbarnoyl-7H-pyrrolo[2,3-d]pyrirri.d.n-2- ylamino)-pyridazine-3-carbonyl]-3,8-diaza-bicyclo[3.2.1 ]octane-8-carboxylic acid tert- butyl ester. In a 4 mL microwave vial 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine- 6-carboxylic acid dimethylarnide (98 mg, 0.336 mmol), 3-(6-amino-pyridazine-3- carbonyl)-3,8-dtaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (112 mg, 0.336 mmol), BINAP (10.5 mg, 0.017 mmol), Cs2C03 (164 mg, 0.504 mmol) and Pd(OAc)z (3.8 mg, 0.017 mmol) were added together. The tube was capped and then purged with N2 three times. Dioxane (1.68 mL) was added and the capped tube was heated to 120C for 20 min in a microwave reactor. After cooling the reaction mixture was diluted with heptane resulting in the crude product precipitating out. The crude product was isolated by filtration, re-suspended in water and subjected to vigorous stirring and sonication. After re-isolating by filtration the product was purified by normal phase silicachromatography with a 0 to 20% eOH/EtOAc gradient which gave a light tan solid (115 mg, 0.195 mmol). MS m/z 590.6 (M+H)+.

According to the analysis of related databases, 1211443-61-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BRAIN, Christopher, Thomas; CHO, Young Shin; GIRALDES, John, William; LAGU, Bharat; LEVELL, Julian; LUZZIO, Michael; PEREZ, Lawrence, Blas; WANG, Yaping; YANG, Fan; WO2011/101409; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia