Adding a certain compound to certain chemical reactions, such as: 1189169-37-6, 1-(5-Bromopyrimidin-2-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1-(5-Bromopyrimidin-2-yl)ethanone, blongs to pyrimidines compound. Recommanded Product: 1-(5-Bromopyrimidin-2-yl)ethanone
At -78 C, n-butyllithium (2.5 M, 0.294 mL, 0.735 mmol) was added to a THF (7.35 mL) solution containing Example 369.0. The resulting mixture was stirred 30 mm at -78 C. Next, a THF solution of 1-(5-bromopyrimidin-2-yl)ethanone (0.208 g, 1.04 mmol) was added at -78C. The reaction was continued at -78 C and allowed to slowly warm to room temp and stirred overnight. The reaction was then quenched with a saturated solution of NH4C1 and extracted with EtOAc (3×1 00 mL). After concentration by solvent removal from the combined organic layers, the reaction was purified on silica eluting with a hexane/EtOAc gradient (0-100%). Desired fractions were then pooled and concentrated in vacuo. The material was then subjected to the reaction conditions described in Example 229.2 to deliver the desired compound. LCMS-ESI (pos.) m/z:695.0, 697.0 (M+H)t
The synthetic route of 1189169-37-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
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