Adding a certain compound to certain chemical reactions, such as: 29274-22-4, Pyrazolo[1,5-a]pyrimidin-5-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 29274-22-4, blongs to pyrimidines compound. Recommanded Product: 29274-22-4
General Procedure 45-(3-Aryl/heteroaryl-prop-2-ynyloxy)-pyrazolo[1,5-a]pyrimidines (54); [00154] A mixture of 4H-Pyrazolo[1 ,5-a]pyrimidin-5-one (0.203 g, 1.5 mmol), 3- aryl/heteroaryl-prop-2-yn-1-ol (1.5 equivalents), P(Ph)3 (2 equivalents) in anhydrous THF was stirred at room temperature for 15 min. Then 2 equivalents of diisopropyl azodicarboxylate (DIAD) was added dropwise and the mixture was stirred at room temperature for 2 h. Control by TLC (eluent: EA/hexane 1 :1 ). After evaporation of solvent the crude residue was purified by column chromatography (eluent: hexane/ethylacetate 1 :1) to give the final compounds.; Example 139 5-(3-Pyridin-2-yl-prop-2-ynyloxy)-pyrazolo[1,5-a]pyrimidine[00315] According to General Procedure 4, 4H-pyrazolo[1 ,5-a]pyrimidin-5-one is reacted with 3-pyridin-2-yl-prop-2-yn-1-ol to provide the title compound in moderate yield. LC/MS: (M+H) = 251
The synthetic route of 29274-22-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERZ PHARMA GMBH & CO. KGaA; HENRICH, Markus; WEIL, Tanja; NAGEL, Jens; GRAVIUS, Andreas; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; FOTINS, Juris; WO2010/63487; (2010); A1;,
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