Related Products of 62802-42-0 ,Some common heterocyclic compound, 62802-42-0, molecular formula is C4H2ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-Fluoro-2-(prop-l-en-2-yl)pyrimidine, Intermediate 5.2.1 A mixture of 2-chloro-5-fluoropyrimidine (50.0 g, 377.0 mmol. CAS: 62802-42-0), potassium trifluoro(prop-l-en-2-yl)borate (84.0 g, 566.0 mmol) and K2CO3 (78.0 g, 566.0 mmol) in 1,4-dioxane (400 mL) and water (100 mL) were added to a sealed tube (1 L). The reaction mixture was degassed and purged with nitrogen for 20 min. PdCl2(dppf) (7.70 g, 9.43 mmol) was added and the reaction tube was sealed and heated to 70 C. After 18 h, the reaction mixture was cooled to RT, diluted with diethyl ether (500 mL), and filtered through Celite filter aid. The filter cake was washed with diethyl ether (500 mL). The combined filtrate was extracted with diethyl ether (2 x 2 L). The organic layer was washed with cold water (2 x 2 L), dried over isfeSCfi and concentrated under reduced pressure at 35 C. The material was purified by column chromatography over silica gel (60-120 mesh) using 5% EtOAc in hexanes as an eluent to give Intermediate 5.2.1 (41.0 g, 297.0 mmol, 79% yield) as a colourless oil. NMR (400 MHz, CDCb) d 8.59 (s, (0466) 2H), 6.38 (t , J= 1.2 Hz, 1H), 5.54 (t , J = 1.2 Hz, 1H), 2.26 (dd, T = 1.2, 0.8 Hz, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62802-42-0, its application will become more common.
Reference:
Patent; AMGEN INC.; PATTAROPONG, Vatee; RAMSDEN, Philip Dean; (203 pag.)WO2019/213006; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia