Adding a certain compound to certain chemical reactions, such as: 4994-86-9, 4-Chloro-2-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-Chloro-2-methylpyrimidine, blongs to pyrimidines compound. Quality Control of 4-Chloro-2-methylpyrimidine
A solution of 4-chloro-2-methylpyrimidine (100 mg, 0.778 mmol), 2-bromo- 5-fluoroisonicotinonitrile (156 mg, 0.778 mmol) and 1,1,1,2,2,2- hexamethyldistannane (255 mg, 0.778 mmol) in 1,4-dioxane (2 mL) was purged with nitrogen gas for 10 min. Pd(Ph3P)4 (90 mg, 0.078 mmol) was added to the reaction mixture and the solution was purged with nitrogen gas again for 10 min. The reaction mixture was heated in a microwave at 150 C for 2 h. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate (20 mL) and water (20 mL). The biphasic mixture was filtered through diatomaceous earth (Celite). The bed was washed with ethyl acetate (25 mL). The organic layer was separated, dried over Na2S04, filtered, and concentrated under reduced pressure. The brown solid was purified by silica gel chromatography (0- 40% EtOAc in pet ether) to afford 5-fluoro-2-(2-methylpyrimidin-4-yl) isonicotinonitrile (40 mg, 0.187 mmol, 24% yield) as an off-white color solid. LCMS (ESI) m/e 215.2 [(M+H)+, calcd for CnH8FN4 215.2]; LC/MS retention time (Method Al): = 1.76 min.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4994-86-9, 4-Chloro-2-methylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BRONSON, Joanne J.; CHEN, Ling; DITTA, Jonathan L.; DZIERBA, Carolyn Diane; JALAGAM, Prasada Rao; LUO, Guanglin; MACOR, John E.; MAISHAL, Tarun Kumar; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; SISTLA, Ramesh Kumar; THANGAVEL, Soodamani; (485 pag.)WO2017/59085; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia