Application of 4359-87-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4359-87-9, name is 2,4,6-Trichloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.
Reference Example 1: N,N-dibenzyl-N’-tert-butyl-2-chloro-5-nitropyrimidine-4,6-diamine To 2,4,6-trichloro-5-nitropyrimidine (, 22.8 g) in methylene chloride(l 70 mL), a solution of tert-butylamine (7.3 g) in methylene chloride (30 mL) was slowly added dropwise at 0 C. To the reaction mixture, diisopropylethylamine (17.3 mL) was slowly added dropwise at 0 C. The reaction mixture was stirred at 0 C for 60 minutes. To the reaction mixture, water was poured and the reaction mixture was extracted with methylene chloride. The obtained organic layer was washed with a saturated saline solution, and was dried over sodium sulfate, and thereafter, was concentrated under a reduced pressure. 12.7 g of the obtained intermediate (27.8 g) was dissolved in methylene chloride (170 mL). To the solution, a solution of dibenzylamine (19.2 mL) in methylene chloride (30 mL) was added dropwise at 0 C. To the reaction mixture, diisopropylethylamine (17.3 mL) was added dropwise at 0 C. The reaction mixture was stirred at 0 C for 60 minutes. To the reaction mixture, water was poured and the reaction mixture was extracted with methylene chloride. The obtained organic layer was washed with a saturated saline solution, and was dried over sodium sulfate, and thereafter, was concentrated under a reduced pressure. The remaining intermediate (15.09 g) was similarly reacted. The obtained crude product was purified by silica gel column chromatography to give the title compound (27.2 g) having the following physical properties. TLC: Rf 0.45 (hexane: ethyl acetate = 9 : 1); 1H-NMR (CDCl3): delta1.51, 4.52, 7.06-7.14, 7.23-7.38, 8.41.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4359-87-9, its application will become more common.
Reference:
Patent; Ono Pharmaceutical Co., Ltd.; YAMAMOTO, Shingo; KURONO, Masakuni; YOSHIDA, Atsushi; HOTTA, Shingo; (53 pag.)EP3560926; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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