A new synthetic route of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235450-86-8, 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1235450-86-8, 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, blongs to pyrimidines compound. Quality Control of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid

A mixture of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid (5.6 g, 24.3 mmol) in xylene (50 mL) was refluxed for 2h. After cooling, the mixture was applied directly to a silica column, which was eluted with petroleum ether, then ethyl acetate in petroleum ether (5%) to give compound 0601-121 (1.7 g, 38%) as a yellow liquid. 1H NMR (400 MHz, DMSO-de): 1.26 (t, J = 7.6 Hz, 3H), 2.87 (q, J= 7.6 Hz, 2H), 8.90 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235450-86-8, 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng; WO2011/130628; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia