Adding a certain compound to certain chemical reactions, such as: 4869-46-9, 1,3-Dimethyluracil-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1,3-Dimethyluracil-5-carboxaldehyde, blongs to pyrimidines compound. name: 1,3-Dimethyluracil-5-carboxaldehyde
General procedure: A mixture of amine 3 (0.1 g, 0.45 mmol) and 5-formyl-N,Ndimethyluracil(17, 0.15 g, 0.9 mmol) in C6H6 was refluxed. When the reaction was finished (TLC monitoring), the mixturewas evaporated. The residue was dissolved in MeOH (1 mL), cooled, treated with NaBH4 (0.22 g, 5.85 mmol), stirred ona magnetic stirrer for 1 h (TLC monitoring), and concentrated. The residue was dissolved in H2O and extracted with CHCl3(5 × 10 mL). The extracts were combined, dried over Na2SO4, and evaporated. The residue was chromatographed over SiO2(eluent EtOAc-hexane, 1:2) to afford 18 (0.1 g, 60%). Amorphous compound, [alpha]D20 -23.0 ( 1.04, CHCl3). Rf 0.5(CHCl3-MeOH, 95:5). C19H25N5O3. IR spectrum (film, nu, cm-1): 3325, 3053, 2935, 2841, 2780, 2740, 2711, 2283, 1701,1663, 1640, 1591, 1565, 1554, 1483, 1458, 1374, 1342, 1274, 1255, 1209, 1183, 1150, 1089, 1041, 1000, 970, 936, 800, 732,699. 1 NMR spectrum (CDCl3, delta, ppm, J/Hz): 1.74 (1H, dtd, J = 12.8, 3.3, 1.2, H-12anti), 1.84 (1H, dtt, J = 12.8, 3.4, 1.7,H-12syn), 2.14 (3H, s, H-1???), 2.22-2.25 (2H, m, H-4ex, H-2ex), 2.43 (1H, m, H-5), 2.84 (1H, ddt, J = 10.6, 3.4, 1.7, H-2en),2.90 (1H, m, H-1), 2.95 (1H, ddt, J = 11.0, 3.4, 1.7, H-4en), 3.36 (3H, s, H-7??), 3.37 (3H, s, H-8??), 3.95 (1H, ddd, J = 15.1, 6.8,1.2, H-6ex), 4.12 (2H, s, H-1?), 4.14 (1H, dt, J = 15.1, 1.2, 1.2, H-6en), 5.47 (1H, br.s, H-2?), 5.95 (1H, d, J = 7.4, H-11), 6.19(1H, d, J = 7.4, H-10), 7.15 (1H, s, H-6??). 13C NMR spectrum (CDCl3, delta, ppm): 26.0 (CH2, C-12), 27.8 (CH, C-5), 27.9 (CH3,C-8??), 34.5 (CH, C-1), 37.1 (CH3, C-7??), 40.0 (CH2, C-1?), 46.3 (CH3, C-1???), 50.2 (CH2, C-6), 62.0 (CH2, C-4), 63.0 (CH2,C-2), 105.3 (CH, C-11), 108.2 (CH, C-10), 110.0 (C, C-5??), 135.4 (C, C-9), 136.4 (C, C-11a), 139.6 (CH, C-6??), 151.7 (C,C-2??), 158.0 (C, C-8), 163.2 (C, C-4??). 15N NMR spectrum (CDCl3, delta, ppm): 29.9 (N-3), 53.3 (N-2?), 122.3 (N-1??), 154.9(N-3??), 168.9 (N-7).
The synthetic route of 4869-46-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tsypysheva; Petrova; Koval?skaya; Lobov; Maksimova; Zainullina; Vinogradova; Vakhitov; Vakhitova, Yu. V.; Galin; Chemistry of Natural Compounds; vol. 54; 5; (2018); p. 938 – 946; Khim. Prir. Soedin.; 5; (2018); p. 794 – 801,8;,
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