Extracurricular laboratory: Synthetic route of 2-Chloro-4-methylpyrimidine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13036-57-2, 2-Chloro-4-methylpyrimidine.

Electric Literature of 13036-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13036-57-2, name is 2-Chloro-4-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of intermediate 15(1.04 g, 4.0 mmol) and 6-chloro-7H-purine (640.0 mg, 4.0 mmol) inEtOH (20.0 ml) Et3N (80.1 mg, 0.62 mmol) was added. The reactionmixture was heated to 90 C and stirred for 24 h. The resultingmixture was concentrated under reduced pressure and purified by column chromatography using a solvent gradient of 1-5% MeOH inDCM to give the compound 4k as a white solid. Yield: 970.0 mg,64.2%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13036-57-2, 2-Chloro-4-methylpyrimidine.

Reference:
Article; Yu, Jiang; Zhou, Peiting; Hu, Mingxing; Yang, Liuqing; Yan, Guoyi; Xu, Ruixue; Deng, Yufang; Li, Xinghai; Chen, Yuanwei; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia