With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, molecular weight is 135.1267, as common compound, the synthetic route is as follows.Computed Properties of C5H5N5
1H-pyrazolo [3,4-d] pyrimidin-4-amine (18.0 g, 130.54 mmol) was dissolved in DMF (150 mL),Then, N-iodosuccinimide (45g, 195.81mmol, Aldrich) was slowly added to the reaction solution, and the reaction was stirred at 80 C for 12 hours.Stop heating, cool, add water (200mL) to the reaction solution, suction filter,Washed with water (80 mL), washed with ethanol (60 mL), and dried to obtain 25.8 g of gray solid, yield: 75.7%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Yang Tiping; Zhou Youbo; Zhang Yingjun; Zheng Changchun; Luo Ming; Li Shixi; Peng Dahua; Wu Shuang; Xiong Jinfeng; (203 pag.)CN107344940; (2020); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia