Electric Literature of 120747-84-4, Adding some certain compound to certain chemical reactions, such as: 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde,molecular formula is C5H5N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120747-84-4.
Sodium triacetoxy borohydride (883 mg, 4.166 rnmol) was added slowly at 0 C to a solution of (trans)-2-(4-(benzyloxy)phenyl)cyclopropanamine (Intermediate B, 500 mg, 2.083 mmol), 2-aminopyrimidine-5-carbaldehyde (256 mg, 2.083 mmol) in DCE (10 mL) and stirred for 20 h. After completion, the solvent was evaporated. The residue was dissolved in Methanol (15 mL), NaBH4 (237 mg, 6.249 mmol) was added slowly at 0 C and stirred for 3 h. After completion, the solvent was evaporated, the residue was dissolved in ice water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic layers were washed with brine (20 mL) and dried over anhydrous Na2S04; filtered and evaporated. The crude residue was purified by prep HPLC to afford 5-(((tran_?)-2-(4- (benzyloxy)phenyl)cyclopropylamino)methyl)pyrimidin-2-amine (180 mg, 25 %) as white solid. .H-NMR (400 MHz, DMSO-d6) delta (ppm): 0.85 (q, 1H), 0.90 (quin, 1H), 1.73 (m, 1H), 2.07 (m, 1H), 2.75 (brs, 1 H), 3.53 (s, 2H), 5.04 (s, 2H), 6.46 (s, 2H), 6.85 (d, 2H), 6.92 (d, 2H), 7.33 (m, 1H), 7.42 (m, 4H), 8.1 1 (s, 2H). Mass (M+H): 347.3
According to the analysis of related databases, 120747-84-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ORYZON GENOMICS S.A.; ORTEGA MUNOZ, Alberto; FYFE, Matthew, Colin, Thor; MARTINELL PEDEMONTE, Marc; TIRAPU FERNANDEZ DE LA CUESTA, Inigo; ESTIARTE-MARTINEZ, Maria de los Angeles; WO2012/13728; (2012); A1;,
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