Synthetic Route of 874676-81-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 874676-81-0, name is 5-Chloro-2-iodopyrimidine. A new synthetic method of this compound is introduced below.
A solution of 4-((l r,4r)-4-(4-(methylsulfonyl)phenoxy)cyclohexyloxy)piperidine hydrochloride (30 mg, 0.077 mmol), 5-chloro-2-iodopyrimidine (28 mg, 0.12 mmol), and Et3N (20 mg, 0.20 mmol) in IPA (1 mL) was stirred for 3 h at 85 C. The reaction was cooled to room temperature to form a precipitate. The solid was filtered, washed with H20, 1 N HC1, IPA, and dried to give the title compound (30 mg). LCMS m/z = 466.2 [M+H]+; lU NMR (400 MHz,CDC13) delta 1.45-1.65 (m, 6H), 1.84-1.92 (m, 2H), 1.97-2.04 (m, 2H), 2.08-2.16 (m, 2H), 3.02 (s, 3H), 3.38-3.46 (m, 2H), 3.54-3.60 (m, IH), 3.63-3.70 (m, IH), 4.18-4.26 (m, 2H), 4.37-4.45 (m, IH), 6.99 (d, J = 8.8 Hz, 2H), 7.84 (d, J = 8.8 Hz, 2H), 8.20 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,874676-81-0, 5-Chloro-2-iodopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; BUZARD, Daniel J.; LEHMANN, Juerg; NARAYANAN, Sanju; YUE, Dawei; WO2011/127051; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia