With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14001-66-2, name is 5-Bromo-2-methoxypyrimidine, molecular formula is C5H5BrN2O, molecular weight is 189.01, as common compound, the synthetic route is as follows.SDS of cas: 14001-66-2
General procedure: To a well stirred solution of substituted internal alkenyltrifluoroborate and the aryl/heteroarylbromides, Cs2CO3 in toluene/H2O (10:1) was added Pd(PPh3)4 and heated to reflux. After 16 h, the reaction was cooled to room temperature and diluted with water. The reaction mixture was extracted with ethyl ether (3x mL). The organic layer was washed with 2N HCl. The aqueous layer was washed with ether and then neutralized with 2N NaOH and extracted with ethyl ether. The organic layer was dried (Na2SO4). The solvent was removed in vacuo and this usually gave clean product. If necessary the crude material was further purified by silica gel column chromatography (elution with EtOAc/MeOH 19:1): The products were usually obtained as a clear pale yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,14001-66-2, 5-Bromo-2-methoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Math, Shivanand K.; Mokri, Homayoun H.; Lamunyon, James B.; Cefalo, Dustin R.; Testa, Charles A.; Tetrahedron Letters; vol. 53; 23; (2012); p. 2847 – 2849;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia