Synthetic Route of 6320-15-6 , The common heterocyclic compound, 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The 3,5-dimethylbenzene acetonitrile (725mg, 5mmol) was dissolved in 40ml DMF, underice-cooling conditions , added NaH (120mg, 5mmol). Under the protection of nitrogen gas stirred for 1 hour, the system changed from colorless to red winecolor, afterwards added 2,4-dimethoxy-6-chloropyrimidine (924mg,5mmol). At theroom temperature stirred for 48 h, pass the air into the reaction system and stirringwas continued for 48~72 hours. The reaction was stopped , after the solvent wasdistilled off under reduced pressure added 200ml water to adjust the PH toneutral with hydrochloric acid. Extracted with Ethyl acetate (100ml X 3),combined the organic phases and for drying added Anhydrous sodium sulfate.Purified through column chromatography (petroleum ether / ethyl acetate) to obtaina pale yellow solid. Yield 89%; melting point. 110-112 C
The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Peking University; LIU, JUNYI; LI, CHAO; WANG, XIAOWEI; ZHANG, ZHILI; GUO, YING; TIAN, CHAO; (12 pag.)CN104119283; (2016); B;,
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