Synthetic Route of 6328-58-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6328-58-1, name is 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, molecular formula is C6H8N2OS, molecular weight is 156.21, as common compound, the synthetic route is as follows.
[00588] To solution of 6-methyl-2-(methylsulfanyl)-3,4-dihydropyrimidin-4-one Intermediate 1 Step 1 (EV-AO5743-001, 7 g, 44.8 mmol) in water (50ml) and dioxane (100ml) was added NaOH (2.15 g, 53.8 mmol) followed by l-(chloromethyl)-4- methoxybenzene (8.42 g, 53.8 mmol) and stirred at 50 C for 1 h. The reaction mixture was cooled to r.t. and the resultant precipitate filtered under vacuum and purified by chromatography on Si02, eluting with Heptane/EtOAc (gradient 100:0 – 0: 100) to afford the title compound (1.54 g, 11.4%) as an oil. [00589] Method A: LC-MS: m z = +277.0 (M+H)+; RT = 1.40 min.
The chemical industry reduces the impact on the environment during synthesis 6328-58-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; QUARTET MEDICINE, INC.; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); TEBBE, Mark, Joseph; ATTON, Holly, Victoria; AVERY, Craig; BROMIDGE, Steven, Mark; KERRY, Mark; KOTEY, Adrian, Kotei; MONCK, Nathaniel, J.; MENICONI, Mirco; RIDGILL, Mark, Peter; TYE, Heather; SAIAH, Eddine; JOHNSSON, Kai, Peter; GORSKA, Katarzyna, Irena; PENG, Hairuo; MCCALL, John, Michael; (356 pag.)WO2017/59191; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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