Synthetic Route of 2227-98-7 ,Some common heterocyclic compound, 2227-98-7, molecular formula is C6H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
9-Deazaadenine [20] (1.49 g, 1.1 equiv), and then formaldehyde (aq, 37 mass%, 1.56 mL, 2 equiv) were added to a solution of amine 46 [21] (2.38 g, 10.1 mmol) in EtOH (20 mL) and H2O (10 mL). The resulting suspension was warmed to 60 C and stirred for 2 h. Silica gel (10 g) was added, solvents evaporated and the resulting solid purified by chromatography (10% 7 N NH3 in MeOH – CHCl3) to afford the title compound 47 (2.00 g, 52%) as a white solid. 1H NMR(CD3OD, 500 MHz) delta 8.17 (s, 1H), 7.46 (s, 1H), 7.33-7.17 (m, 5H), 3.90(dd, J = 11.8, 4.3 Hz, 2H), 3.80 (s, 2H), 3.60 (s, 2H), 3.53 (dd, J = 11.8,7.3 Hz, 2H), 2.42 (d, J = 7.5 Hz, 2H), 2.02-1.95 (m, 1H), 1.32 (s, 3H),1.20 (s, 3H). 13C NMR (d4-MeOH, 126 MHz) delta 152.0, 150.8, 147.2,141.0, 130.0, 129.7, 129.2, 127.9, 115.2, 113.8, 99.2, 64.1, 60.2, 53.6,48.6, 33.8, 25.4, 23.3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2227-98-7, its application will become more common.
Reference:
Article; Mason, Jennifer M.; Yuan, Hongling; Evans, Gary B.; Tyler, Peter C.; Du, Quan; Schramm, Vern L.; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 793 – 809;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia