Reference of 84905-80-6, Adding some certain compound to certain chemical reactions, such as: 84905-80-6, name is 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84905-80-6.
To a solution of 4-chloro-5H-pyrrolo[3,2-d]pyrimidine (25.0 g, 162.8 mmol) in THF (700 ml_) was added N-iodosuccinamide (40.1 g, 179 mmol) at the resulting mixture was stirred for 4 h at RT and then was concentrated in vacuo. The residue triturated in Et20, the resulting solid was collected by filtration and washed with Et20. The crude compound was purified by_silica gel column chromatography eluting with 20-30% EtOAc/petroleum ether to afford 4-chloro-7-iodo-5H- pyrrolo[3,2-d]pyrimidine (CH6) as a yellow solid (32.0 g, 70%); LC-MS. Rt 2.29 min, (0854) AnalpH2_MeOH_4min(1 ); (ESI+) m/z 280.0, 282.0 [M+H]+.
According to the analysis of related databases, 84905-80-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IMPERIAL INNOVATIONS LIMITED; SCHNEIDER, Michael; NEWTON, Gary; CHAPMAN, Katie; PERRIOR, Trevor; JARVIS, Ashley; LOW, Caroline; AQIL, Rehan; FISHER, Martin; BAYFORD, Melanie; CHAPMAN, Nicholas; MARTIN, Nicholas; REISINGER, Tifelle; NEGOITA-GIRAS, Gabriel; (260 pag.)WO2019/73253; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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