Synthetic Route of 22536-61-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22536-61-4, name is 2-Chloro-5-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
[000121] To a stirring solution of 2-chloro-5-methylpyrimidine 80 (5 g, 38.89 mmol) in CC (250 mL) under inert atmosphere were added N-bromosuccinimide (6.92 g, 38.89 mmol) and benzoyl peroxide (706 mg, 2.91 mmol) at RT; heated to 85 °C and stirred for 16 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was filtered. The filtrate was concentrated in vacuo to obtain the crude. The crude was purified through silica gel flash column chromatography using 7percent EtOAc/ hexanes to afford crude compound 81 (5 g, mixture of SM and product in the ratio of ~1: 1) as pale yellow solid. TLC: 20percent EtOAc/ hexanes (R/. 0.5); LC-MS: 55.30percent; 208.8 (M++l); (column; Ascentis Express C18, (50 chi 3.0 mm, 2.7 muiotaeta); RT 1.79 min. 0.025percent Aq. TFA + 5percent ACN: ACN + 5percent 0.025percent Aq. TFA, 1.2 mL/min);
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22536-61-4, 2-Chloro-5-methylpyrimidine.
Reference:
Patent; ASSEMBLY BIOSCIENCES, INC.; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; TURNER, William; ARNOLD, Lee, Daniel; MAAG, Hans; BURES, Mark; (99 pag.)WO2017/48954; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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